Cost-Effectiveness evaluation of Ambulatory and Hospital Care for MDR-TB Treatment in Pakistan: A Randomized Controlled Trial.
Authors
- Razia Fatima, Ankasha Arif, Eatzaz Ahmad, Farzana Naheed, Malik Shahzad Shabbir
Keywords:
Cost-effectiveness, DALYs, Ambulatory care, Hospital Care, MDR-TB, Pakistan.Abstract
The rank of Pakistan is fourth in the high multidrug resistance tuberculosis (MDR-TB) burden countries. To combat the disease in a resource-scarce setting, it is important to explore treatment regimens that are safe, efficient, and cost-effective. A decision tree model is employed for cost-effectiveness analysis (CEA) of treatment arms, quantifying their value through incremental costeffectiveness ratios (ICER). In 2012-2017, randomized control trials were conducted in Lahore, Murree, and Karachi comparing two MDR-TB treatment care arms by collecting the data of 342 newly diagnosed patients. The results show that continuous dominance is not depicted by either arm while both demonstrated their value in reducing the disease burden for MDR-TB patients in Pakistan. Hence both approaches can be simultaneously considered viable strategies for treatment.
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